November 03, 2024
Gout is often associated with drinking too much or not eating healthily enough, but new research suggests genetics play more of a factor in developing the arthritic condition than previously thought.
The research, carried out by an international team of scientists, looked at genetic data collected from 2.6 million people across 13 different cohorts of DNA data. That number included 120,295 people with "prevalent gout".
By comparing the genetic codes of the people with gout against the people without, the team found 377 specific DNA regions where there were variations specific to having the condition – 149 of which hadn't been previously linked to gout.
While lifestyle and environmental factors are certainly still in play, the findings suggest genetics play a major role in determining whether or not someone gets gout – and the researchers think there may be more undiscovered genetic links still to be found, too.
"Gout is a chronic disease with a genetic basis and is not the fault of the sufferer – the myth that gout is caused by lifestyle or diet needs to be busted," says epidemiologist Tony Merriman, from the University of Otago in New Zealand.
Gout takes hold when there are high levels of uric acid in the blood, which then form sharp crystal needles in the joints. When the body's immune system starts to attack those crystals, it leads to significant pain and discomfort.
Genetics is important in every stage of that process, the researchers suggest. Particularly, it affects the likelihood of the body's immune system attacking the crystals, and in the way uric acid is transported around the body.
Gout can come and go, but there are treatments available – and the authors behind the new study think misconceptions can put people off getting those treatments. That's a real problem with cases of the condition rising and rising.
"This widespread myth causes shame in people with gout, making some people more likely to suffer in silence and not go and see the doctor to get a preventive drug that lowers urate in the blood and will prevent their pain," says Merriman.
On top of giving us a better understanding of the causes of gout, the new study gives scientists more options to explore when it comes to treatments, particularly in terms of managing the body's immune response to the build up of uric acid. In fact, existing drugs could be repurposed for this job.
There are some limitations to the study: the majority of the data was from people of European ancestry, and some records relied on the self-reporting of gout rather than a clinical diagnosis. Nevertheless, it gives us a much better sense of a health problem that's been afflicting people for centuries.
"We hope that, in time, better and more accessible treatments will become available with the new targets we identified," says Merriman. "Gout deserves more health spend resource and greater prioritization in the health system."
The research has been published in Nature Genetics.
